Airway disease
GSE193816 Asthma Airway Reanalysis
Allergen-challenge airway scRNA-seq reanalysis focused on epithelial remodeling, immune signatures, and donor-aware interpretation.
Srilaxmi Nerella
I work in translational research at UCSF, with a focus on airway disease, immune biology, and epithelial biology. This site highlights selected computational projects, publications, and reproducible single-cell analyses in those areas.
Featured Projects
Cancer TME
GSE131907 Lung Adenocarcinoma TME Reanalysis
Lung adenocarcinoma scRNA-seq reanalysis focused on tissue-site composition, tumor microenvironment signatures, and sensitivity checks.
Selected Publications
Recent and representative work connected to fibrosis, airway biology, immunology, genomics, and single-cell analysis.
Resolving fibrosis by stimulating HSC-dependent extracellular matrix degradation
Science Translational Medicine, 2025. Fibrosis biology and matrix remodeling.
Genetic and non-genetic factors affecting expression of COVID-19-relevant genes in large airway epithelium
Genome Medicine, 2021. Airway epithelial genomics and host factors relevant to viral entry biology.
Single-cell mapping of progressive fetal-to-adult transition in human naive T cells
Cell Reports, 2021. Human T-cell development and single-cell immune profiling.
IFN-stimulated gene expression, type 2 inflammation, and endoplasmic reticulum stress in asthma
American Journal of Respiratory and Critical Care Medicine, 2018. Asthma airway transcriptomics.
Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults
JAMA Psychiatry, 2014. Epigenomics and methylome-wide association analysis.
Research Focus
My current interests center on using reproducible single-cell analysis to connect immune and epithelial cell states with disease context.
Single-cell RNA-seq and multi-sample study design
Immune and epithelial programs in airway disease
Cancer tumor microenvironment analysis
Public GEO reanalysis and reproducible workflows